Carbonic acid diethyl ester
Diethyl carbonate
CAS: 105-58-8
Molecular Formula: C5H10O3
Carbonic acid diethyl ester - Names and Identifiers
| Name | Diethyl carbonate |
| Synonyms | DPD1 TGFB progressive Ethyl carbonate Diethyl carbote Diethyl carbonate diethyl dicarbonate diaphyseal dysplasia 1 Carbonic acid diethyl ester Monoclonal Anti-TGFB1 antibody produced in mouse Anti-TGF β1, C-Terminal antibody produced in rabbit |
| CAS | 105-58-8 |
| EINECS | 203-311-1 |
| InChI | InChI=1/C5H10O3/c1-3-7-5(6)8-4-2/h3-4H2,1-2H3 |
Carbonic acid diethyl ester - Physico-chemical Properties
| Molecular Formula | C5H10O3 |
| Molar Mass | 118.13 |
| Density | 0.975 g/mL at 25 °C (lit.) |
| Melting Point | -43 °C (lit.) |
| Boling Point | 126-128 °C (lit.) |
| Flash Point | 88°F |
| Water Solubility | Negligible |
| Solubility | 18.8mg/l insoluble |
| Vapor Presure | 10 mm Hg ( 23.8 °C) |
| Vapor Density | 4.1 (vs air) |
| Appearance | Liquid |
| Color | Clear |
| Odor | Pleasant, etheral; mild and nonresidual. |
| Merck | 14,3780 |
| BRN | 956591 |
| PH | 6.3 (1g/l, H2O) |
| Storage Condition | no restrictions. |
| Stability | Stable. Flammable. Incompatible with strong acids, strong bases, reducing agents, oxidizing agents. Protect from moisture. |
| Sensitive | Moisture Sensitive |
| Explosive Limit | 1.4-11.0%(V) |
| Refractive Index | n20/D 1.384(lit.) |
| Physical and Chemical Properties | Colorless transparent liquid, slightly irritating odor. melting point -43 ℃ boiling point 126.8 ℃ relative density 0.975 refractive index 1.3846 flash point 32.8 ℃ solubility insoluble in water, soluble in alcohol, ether and other organic solvents. |
| Use | It is used as an intermediate in organic synthesis and drug synthesis, and is also used as a solvent for resins, oils, nitrocellulose and cellulose ethers. |
Carbonic acid diethyl ester - Risk and Safety
| Risk Codes | R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. R10 - Flammable |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S16 - Keep away from sources of ignition. S23 - Do not breathe vapour. |
| UN IDs | UN 2811 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | YE1050000 |
| FLUKA BRAND F CODES | 21 |
| TSCA | Yes |
| HS Code | 2920 90 10 |
| Hazard Class | 3 |
| Packing Group | III |
| Toxicity | LD50 orally in Rabbit: > 4900 mg/kgLC50 (inhalation) > 21 mg/kg (mouse)TDL0 500 mg/kg (mouse)LD50 (s.c.) 8500 mg/kg (rat) |
Carbonic acid diethyl ester - Upstream Downstream Industry
Carbonic acid diethyl ester - Nature
Open Data Verified Data
colorless transparent liquid, slightly irritating odor. Relative density 0.975. Melting Point -43 °c. Boiling point 126.8 °c. Flash point (closed cup) 32.8 °c. Refractive index 3846. Insoluble in water, soluble in alcohol, ether and other organic solvents. Flammable, and the air is easy to form explosive mixture.
Last Update：2024-01-02 23:10:35
Carbonic acid diethyl ester - Preparation Method
Open Data Verified Data
anhydrous ethanol reacts with phosgene to form ethyl chloroformate, and then continues to react with ethanol to form diethyl carbonate. It is then washed with water and distilled to obtain a finished product.
Last Update：2022-01-01 10:33:54
Carbonic acid diethyl ester - Use
Open Data Verified Data
used as a solvent for nitrocellulose, natural and synthetic resins. It is also an important intermediate in organic synthesis for the synthesis of phenobarbital and pyrethroids and for the coating of the cathode in electron tubes.
Last Update：2022-01-01 10:33:54
Carbonic acid diethyl ester - Safety
Open Data Verified Data
- This product is moderately toxic. The eye, skin, mucous membranes have a stimulating effect. During production, the equipment should be sealed and kept well ventilated, and the operators should wear protective equipment to prevent phosgene poisoning.
- This product is packaged in an iron drum with a specification of 160kg. Should be stored in a cool, dry and ventilated place, away from fire. It shall be stored and transported according to the regulations on flammable and toxic dangerous goods.
Last Update：2022-01-01 10:33:55
Carbonic acid diethyl ester - Reference Information
Open Data Unverified Data
| LogP | 1.21 at 25℃ |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| uses | mainly used as cellulose ethers, nitrocellulose, natural and synthetic resin solvents, also used in the synthesis of phenobarbital, pyrethroids and so on diethyl carbonate is an important intermediate in organic synthesis. Mainly used as nitrocellulose, cellulose ether, synthetic resin and natural resin solvent, pesticide pyrethroid and drug phenobarbital intermediates. It is used in the instrumentation industry to prepare fixative paints for the sealing and fixing of the cathode of an electron tube. used as intermediates in organic synthesis and drug synthesis, also used as resins, oils, solvents such as nitrocellulose and cellulose ethers are used as solvents and solvents for organic synthesis of natural resins. Nitrocellulose, cellulose ether synthesis. Organic Synthesis. The electrolyte used in the industry is mainly used in rechargeable lithium ion batteries, and can only be used in a dry environment (e. G., in a glove box with ambient moisture less than 20ppm). used as solvent, also used in organic synthesis |
| production method | anhydrous ethanol reacts with phosgene to produce ethyl chloroformate, and then continues to react with ethanol to form diethyl carbonate. It is then washed with water and distilled to obtain a finished product. Raw material consumption quota: ethanol 1450kg/t, phosgene 22250kg/t. |
| category | flammable liquid |
| toxicity grade | low toxicity |
| Acute toxicity | oral-rat LDL0: 15000 |
| flammability hazard characteristics | in case of open flame, high temperature, flammable oxidant; Combustion stimulus smoke |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; It is stored separately from the oxidant |
| extinguishing agent | dry powder, dry sand, carbon dioxide, foam, 1211 extinguishing agent |
| spontaneous combustion temperature | 445°C |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 19:43:38
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